The renowned Mayo Clinic will run Sheikh Shakhbout Medical City (SSMC) alongside the capital's public hospital operator Seha.
SSMC began accepting patients this month and will fully open in early January.
Mayo Clinic officials did not disclose any levels of financial commitment but patients will have access to the top surgeons of the clinic - some of whom will work at SSMC.
The first preference will be given to the people from Abu Dhabi, then it will develop this into a facility to attract patients from all over the world."
Mayo Clinic is known for its pioneering treatment and over the course of the next few months, doctors, surgeons and clerical staff from the US will begin working at the hospital.
It also expects to introduce some of the most advanced technology to tackle conditions such as cancer. These contain proton beam treatment - an advanced form of radiotherapy.
"To become an international destination, there are pieces we want to add," said William Stone, vice dean of clinical practice at Mayo Clinic.
"Things such as bone marrow transplant. Also proton beam therapy and large particle therapy for cancer. There are a host of things not present here that we hope to bring in the future."
SSMC has about, 18 operating rooms, 700 beds, four wings, and a surgical robot.
It opened quietly a few weeks ago but by the time it is fully operational, the hospital expectations to have at least 4,000 staff and treat up to 3,000 outpatients a day.
Even the colors of the walls are chosen to encourage moods with shades of blues and violets deployed in diagnosis areas to lower stress levels.
"Over course of time there will be changes to meet our needs and patient needs," said Mr. Stone.
SSMC has four towers dedicated to children and maternity, surgical specialties, medical specialties and burns, and critical care.
Saeed Al Kuwaiti, head of SSMC’s operation committee, said what makes the hospital different is that it covers so many specialties.
“The best advantage is the location, which is on two major highways between Abu Dhabi, Al Ain, Dubai, and Al Dhafra, making it the ideal location for trauma patients," said Mr. Al Kuwaiti.
“We will be accepting all patients, regardless of their insurance. The government has invested a lot into SSMC and we are confident of the quality of services we will be offering patients.”
Sheikh Abdulla bin Mohammed Al Hamed, chairman of the Department of Health, Abu Dhabi, said the collaboration was helping establish the emirate as "a global destination for health care".
"The nation's founding fathers and wise leadership set in motion a vision to deliver world-class health care for the people of the Emirates,” he said.
“This has meant significant investment over the years and the development of substantial health care services across the country."